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One of the first uses of the word in this way was in 1941 by author G. HIV-1 in his preserved blood and tissues. The nutritionist will then meet with the participants each month to establish a plan that will reinforce healthy eating habits within the family. Pesticides and other chemicals used in farming can also be hazardous to worker health, and workers exposed to pesticides may experience illnesses or birth defects. APhA founders felt this could not be accomplished without first developing a formalized education system. Meta-analyses have found that injections of allergens under the skin are effective in the treatment in allergic rhinitis in children and in asthma. The effect of a particular cytokine on a given cell depends on the cytokine, its extracellular abundance, the presence and abundance of the complementary receptor on the cell surface, and downstream signals activated by receptor binding; these last two factors can vary by cell type. 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